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[thrombin-derived C-terminal peptides] Papareddy et al (2010) have shown that, by functioning as host defense peptides, C-terminal peptides of thrombin, a key enzyme in the coagulation cascade, link the coagulation system and host-defense peptides, two fundamental biological systems activated in response to injury and microbial invasion.


The major peptide comprises the C-terminal 96 amino acids of thrombin (thrombin(527-622)). VFR17 (17-mer; VFRLKKWIQKVIDQFGE) and the longer 25-mer peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE ... ... ... ... ... Subscribe to continue reading! ... ...

 

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