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[Spodoptera littoralis inhibitor of apoptosis] The gene encoding this protein (15 kDa) has been identified in the genome of the Spodoptera littoralis nucleopolyhedrovirus (SINPV). The sequence contains one BIR domain and a RING finger found also in other members of the IAP family of proteins. Sliap can delay, but not suppress, cell death by apoptosis induced by replication of a baculovirus lacking expression of the baculovirus p35 protein.
Vilaplana et al (2007) have reported that a ramatic decrease of Sliap expression coincides with midgut cell death during metamorphosis.
For other entries pertaining to cell death mechanisms see also the Apoptosis and Cell Death Dictionary
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