Scolopendin 1 |
Scolopendrasin III |
ribosomal protein L40 |
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Scolopendin 2, AGLQFPVGRIGRLLRK, is derived from the centipede Scolopendra subspinipes mutilans. The peptide shows antimicrobial activity in a salt-dependent manner against various fungal and bacterial pathogens and shows no hemolytic effect in the range of 1.6 μM to 100 μM. The peptide forms pores in the membranes of Escherichia coli O157 and Candida albicans, resulting in loss of intracellular potassium ions, and causes membrane depolarization. The peptide is active against Gram-positive Enterococcus faecium, Staphylococcus aureus, and methicillin resistant Staphylococcus aureus (MRSA), Gram-negative Escherichia coli
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