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Sapecin

Sapecin is a peptide of 40 amino acid (ATCDLLSGTGINHSACAAHCLLRGNRGGYCNGKAVCVCRN) purified from the conditioned medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina (flesh fly) (Matsuyama and Natori, 1988). The protein contains three disulfide bridges essential for bioactivity (Kuzuhara et al, 1990). A homolog of Sapecin, termed holotricin-1, has been isolated from the coleopteran insect, Holotrichia diomphalia.

Sapecin preferentially represses the growth of various Gram-positive bacteria. The gene for the sapecin precursor is activated in the hemocytes ... ... ... ... ... Subscribe to continue reading! ... ...

 

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