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svVEGF |
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this peptide (Ser-Leu-Ala-Tyr-Gly-Leu-Arg), corresponding to osteopontin(162-168) (OPN(162-168)), is a cryptic peptide sequence located adjacent to the RGD sequence in osteopontin that is exposed after thrombin cleavage of osteopontin at Arg168 (yielding an N-terminal fragment containing C-terminal SVVYGLR) (Yokosaki Y et al, 1999). The corresponding sequence in mouse osteopontin is SLAYGLR (Scatena et al, 2007).
SVVYGLR binds the integrins integrin-alpha-4 /
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