SPINK4 |
SPINK5L3 |
CD27 binding protein |
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[Serine protease inhibitor Kazal-type 13]. A databank synonym is SPINK5L3 [Serine protease inhibitor Kazal-type 5-like 3].
This rat protein, identified originally in Macaca mulatta as an epididymis-specific gene termed ESC6 [epididymis-specific clone 6] (Liu et al, 2001), has been identified by Ma et al (2013) as an androgen-responsive serine protease inhibitor that binds to the sperm acrosome region and is essential for sperm maturation. Knock-down of SPINK13 in vivo dramatically enhances the acrosomal exocytosis during capacitation and significantly reduces male fertility.
The protein has been identified independently as
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