SPDCA
[Serine protease dependent cell apoptosis] This kind of cell death differs from cell death by apoptosis in that it does not require the activation of caspases (see also: CICD, caspase-independent cell death) but rather depends on serine proteases as critical effectors of the apoptotic process.
The observation that particular apoptotic events can be prevented by broad-range inhibitors of serine proteases such as TLCK, TPCK or AEBSF (Egger et al, 2003; Liu et al, 2004; Thorburn et al, 2003) together with the observation that inhibition of caspases by suitable inhibitors may fail to prevent cell death
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