SPAP1C |
SPAP2A |
CtBP-interacting BTB zinc finger protein |
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[SH2 domain-containing phosphatase anchor protein-2] SPAP2 is a transmembrane protein characterized by Xu et al (2002). The extracellular portion of SPAP2 contains six immunoglobulin-like domains and its intracellular segment has two ITAM motifs and two ITIM motifs, suggesting a role as an activating/inhibitory receptor. SPAP2 mRNA is expressed in restricted human tissues including the kidney, salivary gland, adrenal gland, uterus, and bone marrow. Tyrosine-phosphorylated SPAP2 is specifically associated with SH2 domain-containing tyrosine kinases Syk and ZAP70 and SH2 domain containing tyrosine phosphatases SHP1
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