ZAP70
[zeta chain-associated protein kinase 70 kDa, Zeta-associated protein 70] This 70 kDa tyrosine phosphoprotein associates with the zeta chain of the T-cell receptor and undergoes tyrosine phosphorylation following receptor stimulation (Chan et al, 1992; Iwashima et al, 1994). The ZAP70 gene is expressed in T-cells and natural killer cells. The ZAP70 gene maps to human chromosome 2q12.
Mutations in the ZAP70 gene have been shown to occur in patients with severe combined immunodeficiency (SCID; see also: Immunodeficient mice) (Chan et al, 1994; Elder et al, 1994). A mutation of ZAP70 resulting in loss of the activity of this kinase has been shown also to be the underlying cause of a novel type of
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