SARA

[Smad Anchor for Receptor Activation]. The approved gene symbol is ZFYVE9 [zinc finger FYVE domain containing 9]. In databanks the protein is being referred to also as MADHIP [MADH-interacting protein].

This protein of 135 kDa acts as an anchor protein and recruits the SMAD proteins SMAD2 and SMAD3 (Tsukazaki et al, 1998; Goto et al, 2001, Quin et al, 2002) to the TGF-beta receptor (Miyazono et al, 2000). TGF-beta receptors require SARA for phosphorylation of the downstream transducing SMAD proteins and their localisation to endosomes (Itoh et al, 2002; Hayes et al, 2002).

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Entry last modified: January 2013