Sharpin |
sheath cells |
Grb-IR |
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(approved gene symbol) [sex hormone-binding globulin] SHGB, abbr. also SBP, is a plasma protein secreted by the liver. The cDNA has been cloned by Gershagen et al (1989). The protein is identical with ABP [androgen-binding protein] secreted by Sertoli cells. The protein binds sex hormones such as testosterone and is identical with TEBG [testosterone-binding beta-globin; testosterone-estrogen-binding globulin], which binds about 66 % of the testosterone found in plasma, only unbound testosterone being biologically active (Wenn et al, 1977; Raj et al, 1978). Many hirsute women have normal levels of total
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