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SET domain

[SET domains]

The SET domain is an evolutionarily conserved sequence motif of 130 amino acids found in a large number of proteins. The name derives from the three Drosophila proteins Suppressor of variegation 3-9 [Su(var)3-9], Enhancer of zeste [E(Z)], and Trithorax (Trx) (Tschiersch et al, 1994).

SET domains are present in chromosomal proteins that function in modulating gene activities from yeast to mammals. Proteins bearing the SET domain have been shown to methylate lysine residues in histones and other proteins and are being referred to as SET domain lysine methyltransferases (Del Rizzo and Trievel, 2011) and thus play a role in the epigenetic control of gene expression.

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