SEF

[similar expression to FGF] This human gene, which shows limited homology to the intracellular domain of members of the IL17 receptor family and has been referred to also as IL17RD [interleukin-17 receptor D; IL17 receptor D] (which is also the approved gene symbol). Human SEF has been isolated following a search for proteins expressed in human umbilical vein endothelial cells (Haudenschild et al, 2002; Yang et al, 2003) (see entry IL17RD for isoforms).

The human SEF is the homolog of the zebrafish SEF gene, which functions as a feedback-induced antagonist of Ras/Raf/MEK/MAPK-mediated FGF ... ... ... ...
 
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Entry last modified: January 2010