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SCUBE1

[Signal peptide-CUB-EGF-like domain containing protein 1] This protein is secreted by human vascular endothelial cells from various highly vascularized tissues (Yang et al, 2002). Tu et al (2006) have reported expression in platelets. SCUBE1 contains 10 EGF-like domain and one CUB domain at the carboxyl terminus. Another designation for this protein, which reflects the presence of EGF-like domains, is EGF-like domain containing protein-1. Secreted SCUBE1 can form oligomers and stably associates with the cell surface. A related protein, designated SCUBE2 is expressed also in endothelial cells and other cell types and can form a heteromeric complex with SCUBE1.

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