SAHGTSTGVPWP |
Saka |
TSARG2 |
||
[Snk/Plk-akin kinase] This protein is a member of a family of polo-like kinases (see also: Plk-1 [polo-like kinase-1]). The approved gene symbol is PLK4 [polo-like kinase 4]. A previous HGNC symbol is STK18 [Serine/threonine-protein kinase 18]. Karn et al (1997) have cloned the cDNA encoding the human enzyme.
Expression of the gene is strongly repressed by wild-type p53 and its expression is downregulated by wild-type p53 in several tumor cell models.
Inhibition of SAK expression by RNA interference induces cell death by apoptosis. SAK overexpression attenuates p53-induced
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |