Rift Valley fever virus NSm protein |
Rig |
Caenopores |
||
[RVFV NSs protein; NSs protein] This protein is a non-structural protein encoded in the genome of Rift Valley fever virus. NSs is a virulence factor that blocks nnate immunie responses by downregulating the antiviral type 1 interferon (IFN-alpha, IFN-beta) responses (Billecocq et al, 2004; Bouloy et al, 2001). The protein also downregulates the expression of the double-stranded RNA-dependent protein kinase (PKR), which constitutes a substantial part of the antiviral activity of interferon against RVFV (Habjan et al, 2009; Ikegami et al, 2009), and inhibits eIF2-alpha phosphorylation Ikegami et al, 2009).
The protein also interferes with host transcription by promoting the proteasomal degradation of p62, a subunit of the general transcription factor
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |
| SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
| # | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
|
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R