Retbindin

approved gene symbol: RTBDN. Retbindin, identified originally as an expressed sequence tag by Wistow et al (2002) is a retina-specific protein of unknown function. It is secreted by rod photoreceptor cells into the inter-photoreceptor matrix. Retbindin is localized predominantly at the interface between photoreceptors and the microvilli of retinal pigment epithelium cells, a region critical for retinal function and homeostasis. In vitro, retbindin is capable of binding riboflavin, thus implicating the protein as a metabolite carrier between the retina and the retinal pigment epithelium (Kelley et al, 2015).

Kelley RA et al (2017) have reported that retbindin plays a critical role in the acquisition and retention of flavins in the neural retina. Knock-out mice ... ... ... ...
 
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Entry last modified: September 2023