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RaRF p28A

[Ra-reactive factor p28A] This protein, found in sera of nonimmune mice never stimulated with exogenous Ra antigen (a rough variant of LPS), is a complement-dependent bactericidal factor that acts specifically on Ra chemotype strains of Salmonella (Kawakami et al, 1982). Kuge et al (1992) have cloned the cDNA.

Ra-reactive factor proteins, which is produced by hepatocytes, is composed of a component that binds polysaccharide (two 28 kDa polypeptides, P28a and P28b), and a component that is presumably responsible for complement activation. Partial amino acid sequences of P28a and P28b indicate that these polypeptides are similar to two species of mannose-binding protein, MBP-C [mannan-binding protein C] and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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