RNF128 |
RNF136 |
CSIPPEVKFNKPFVYLI |
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(approved gene symbol) [RING finger protein 135] This designation refers to the presence of a RING finger domain. The protein has been shown to be involved in innate immune responses against RNA virus infection
Gao et al (2009) have identified the protein as REUL [RIG-I E3 ubiquitin ligase], showing that it acts as an E3 ubiquitin liagse and stimulator of RIG-I, specifically stimulating RIG-I-mediated innate antiviral activity. The protein ubiquitinates full-length RIG-I, but not a CARD domain deletion mutant of RIG-I. Overexpression of the protein potently potentiates RIG-I downstream signalling and antiviral activity. In contrast, the
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