RNF135

(approved gene symbol) [RING finger protein 135] This designation refers to the presence of a RING finger domain in the protein. The protein has been shown to be involved in innate immune responses against RNA virus infection

Gao et al (2009) have identified the protein as REUL [RIG-I E3 Ubiquitin Ligase], showing that it acts as an E3 ubiquitin liagse and stimulator of RIG-I, specifically stimulating RIG-I-mediated innate antiviral activity. The protein ubiquitinates full-length RIG-I, but not a CARD domain deletion mutant of RIG-I. Overexpression of the protein potently potentiates RIG-I downstream ... ... ... ...
 
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Entry last modified: July 2015