RNF124 |
RNF128 |
retinospheres |
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[RING finger protein 125] This designation refers to the presence of a RING finger domain. RNF125 is an E3 ubiquitin ligase (Zhao et al, 2005; Giannini et al, 2008). The protein has been described independently as TRAC1 [T-cell RING activation protein 1] (Zhao et al, 2005). The potein is expressed in CD4(+) and CD8a(+) T-cells and is involved as a positive regulator in the cell activation of T-cells through the T-cell receptor.
RNF125 has been implicated in innate immune responses. Arimoto et al (2007) have reported that RNF125 ubiquitinates dsDNA sensors RIG-I, MDA-5, as well as
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