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Q-VD-OPh

abbr. often: qVD, Q-Val-Asp-OPH. 5-(2,6-difluorophenoxy)-3-[[3-methyl-2-(quinoline-2-carbonylamino)butanoyl]amino]-4-oxopentanoic acid. Known also as Quinoline-Val-Asp-Difluorophenoxymethylketone.

This compound is a broad spectrum inhibitor for caspases. Q-VD-OPh is not toxic to cells even at extremely high concentrations. Q-VD-OPh consists of a carboxy terminal phenoxy group conjugated to the amino acids valine and aspartate. The compound is a potent inhibitor of cell death by apoptosis and is significantly more effective in preventing apoptosis than ZVAD-fmk and Boc-D-fmk. It is equally effective in preventing apoptosis ... ... ... ... ... Subscribe to continue reading! ... ...

 

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