Parasin-1

This peptide of 19 amino acids (KGRGKQGGKVRAKAKTRSS; Lys-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser) is secreted into the epithelial mucosal layer in response to epidermal injury by catfish (Parasilurus asotus) (Park et al, 1998). 18/19 residues in parasin-1 are identical to the N-terminal sequence of buforin-1, a 39-residue antimicrobial peptide derived from the N-terminal of toad histone H2A. Parasin-1 also shares 89 % homology with the N-terminus of human histone H2A variant H2A.5.

The peptide corresponds to histone H2A(1-19) and is generated by cleavage of unacetylated histone H2A ... ... ... ...
 
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Entry last modified: June 2009