PGSF

[paracrine growth-stimulatory factor] This biochemically uncharacterized factor of approximately 30 kDa was found in the conditioned medium of a spontaneously transformed rat liver epithelial cell line grown in serum-free medium.

PGSF stimulates the proliferation of NRK cells and induces anchorage-independent growth in soft agar culture (see also: Colony formation assay) without EGF or TGF-beta. PGSF slightly inhibits the growth of the spontaneously transformed rat liver epithelial cells, which also appear to elaborate an unidentified low molecular weight autocrine growth-stimulatory factor ( ... ... ... ...
 
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Entry last modified: November 2012