P-glycoprotein

[permeability glycoprotein]; abbr. also p-gp; this is the same as P-glycoprotein-1. This protein has been identified as a cell surface glycoprotein of 170 kDa in Chinese hamster ovary cells selected for resistance to colchicine (Juliano and Ling, 1976). The protein is not found on found on wild-type cells. Drug-resistant cells show reduced rates of drug permeation and display pleiotropic cross-resistance to a wide range of amphiphilic drugs. Ueda et al (1986) have shown that the MDR-1 gene codes for P-glycoprotein, which has been identified also as gp170.

In the nomenclature of CD antigens this protein has been given the designation CD243.

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