NleE

[non-LEE-encoded effector E] NleE is found in enteropathogenic and enterohemorrhagic Escherichia coli. NleE is one of several gene encoding virulence factors. The term refers to the fact that these genes and a large group of other pathogenicity-related genes are not encoded by a pathogenicity island in chromosome known as the LEE [locus of enterocyte effacement] (for overview see also: Dean and Kenny, 2009).

The pathogen inhibits inflammation responses of the host by injecting NleE into host cells. NleE blocks the activation of IKK-beta and consequently the degradation of the NF-kappa-B inhibitor, I-kappa-B, and thus blocks the NF-kappa-B pathway, which regulates the expression of genes associated with ... ... ... ...
 
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Entry last modified: December 2014