nephroblastostatin |
nephrocan pseudogene |
death-domain associated protein-gamma |
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gene symbol: Nepn; abbr. also: NPN. The human gene appears to be a pseudogene, termed NEPNP [nephrocan pseudogene] (Zhang et al, 2010). Nephrocan is a small leucine-rich repeat secreted protein that can act as a secreted inhibitor of TGF-beta signaling. In adult mice, Nephrocan is expressed mainly in the kidney (Mochida et al, 2006). The protein plays a role in development. It is expressed in the definitive endoderm that emerges during gastrulation, as well as its derivative the gut tube epithelium and the early pancreas primordium (Hou et al, 2014). Loss of Nephrocan affects endoderm
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