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Necrosin

This factor was found initially in the serum-free conditioned medium of the murine macrophage-like cell line J774 that had been treated with bacterial endotoxins. It exists as a multimer of 70 kDa consisting of 15 kDa subunits. The factor is cytotoxic for normal and malignant bovine and human cells lines (Kull and Cuatrecasas, 1984).

Necrosin is identical with TNF-beta.

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