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J774

A murine macrophages cell line established from a tumor that arose in a female BALB/c mouse. Its growth is inhibited by dextran sulfate, purified protein derivative, and bacterial lipopolysaccharides. J774 cells have been used for numerous biochemical studies aimed at understanding the physiology of monocytes and macrophages.

This cell line synthesizes large amounts of lysozyme and exhibits minor cytolysis but predominantly antibody-dependent phagocytosis. The cells have been shown to express cell-bound receptors for immunoglobulin and complement.

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