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NRAGE

[Neurotrophin receptor-interacting MAGE homolog] The approved gene symbol is MAGED1 [melanoma antigen family D1]. The protein is known also as Melanoma-associated antigen D1 and has been identified independently as Dlxin-1.

NRAGE has been identified by Salehi et al (2000) as part of a signaling cascade that mediates cell death by apoptosis and that involves NGF and the neurotrophin receptor p75NTR. In the presence of NRAGE, the two neurotrophin receptor subunits p75NTR and trkA lose their ability to interact. Co-expression of NRAGE and p75NTR, but not trkA, in a ... ... ... ... ... Subscribe to continue reading! ... ...

 

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