NK-RIF |
NKR lymphoid tissue inducer cells |
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[NKR lymphoid tissue inducer cells] This cell type, found in mucosal tissues, has been described by Vonarbourg et al (2010) and is considered a subpopulation of innate lymphoid cells (group 3 innate lymphoid cells).
There are two subpopulations that are distinguished by the expression of transcription factor ROR-gammat-t. IL7 and intestinal microbiota stabilize ROR-gammat-t expression within such cells. IL12 and IL15 accelerate ROR-gammat-t loss.
NKR-LTi cells that express ROR-gammat-t also produce IL-22. NKR-LTi cells that do not express ROR-gammat-t release IFN-gamma and are potent inducers of inflammatory
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