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NKAF

[natural killer cell activating factor] This biochemically uncharacterized factor is secreted by murine lymphocytes after cell activation. It is a positive regulator of immune responses and increases the activity of natural killer cells (Kobayashi et al, 1991; Ichimura et al, 1984; Shitara et al, 1985; Uchida et al, 1986).

The factor is not identical with IL2 or one of the known interferons (see: IFN). Some NKAF activity described as Natural killer cell activity-augmenting factor is due to IL6 (Malejczyk et al, 1992; Luger et al, 1989).

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