NijA |
Nil-2-a |
B-cell derived leukocyte inhibitory factor |
||
[NF-kappa-B-inducing kinase] This serine/threonine kinase is known also as MAP3K14 (mitogen-activated protein kinase kinase kinase-14). The NIK cDNA encodes a protein of 947 amino acids (Malinin et al, 1997). It is involved in the activation of transcription factor NF-kappa-B in response to TNF-alpha, IL1, and FAS antigen. NIK binds to the signal transducer TRAF2.
Yin et al (2001) have generated knock-out mice lacking expression of NIK. Mutant mice lack lymph nodes and an abnormal spleen and thymus architecture. Antibody responses upon immunization are diminished. An analysis of fibroblasts
... ... ... ...
... CONTINUE READING at cells-talk.com,
COPE's new home with 61 100+ entries, 141 552 cited references and >2,5
million internal hyperlinks. This most comprehensive knowledge base provides
extensive in-context information covering nomenclature, terminology, and
highlighting concepts, strategies & complexities of cellular communication
processes. COPE's fully integrated subdictionaries include
Dictionary of Angiogenesis •
Dictionary of Antimicrobial & host defense peptides •
Dictionary of Apoptosis and cell death •
Dictionary of CD antigens •
Dictionary of Chemokines •
Dictionary of Cryptides •
Dictionary of Cytokines & Growth factors •
Dictionary of Eukaryotic cell types & expression profiles •
Dictionary of Hematopoiesis •
Dictionary of Hormones •
Dictionary of Inflamation & inflammatory mediators •
Dictionary of Innate Immunity •
Dictionary of Metalloproteinases •
Dictionary of Moonlighting proteins & cryptides •
Dictionary of Neuropeptides •
Dictionary of Pathogenicity & Virulence Factors •
Dictionary of Pattern recognition receptors •
Dictionary of Protein domains •
Dictionary of Regulatory peptide factors •
Dictionary of Viroceptors •
Dictionary of Virokines •
Dictionary of Stem cells
and more.
An important note about your privacy: A search engine may have brought
you here. If the provided URL differs in any way from
"www.copewithcytokines.org/cope.cgi?key=search term", 3rd parties may
record your activities on COPE. Bypass snoopers by doing this: Go
directly to cells-talk.com or go to
copewithcytokines.org
in a new browser tab and from there explore whether COPE contains the terms
that interest you. The private bioinformatics initiative COPE at
cells-talk.com
never shares your search histories or user databank entry with 3rd parties.
SUPPORT COPE | Intro | Subdictionaries | New Entries | Contribute data | COPE Credentials |
# | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
Created, developed, and maintained by Dr H Ibelgaufts
|
U L T R A P O S S E N E M O O B L I G A T U R