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NDPP-1

This protein of 41 kDa contains long stretches of leucine and proline residues at its N-terminus. Expression of the gene is downregulated during mouse embryonic brain development. The gene is expressed also at high levels in heart and testis of adult mice. It is detected in embryonic carcinoma and pheochromocytoma cell lines, but not in fibroblasts (Sazuka et al, 1992). The gene has been cloned by Zhang and Fu (2002) who reported that NDPP-1 mRNA expression is higher in the kidney and testis of normal tissues. High expression is also detected in breast cancer, prostate cancer and granulosa tumor cells but not in bladder cancer cells. NDPP-1 supresses apoptosis in REF52 cells induced by ... ... ... ... ... Subscribe to continue reading! ... ...

 

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