NAMLAA

[N-acetylmuramoyl-L-alanine amidase] Called also mucopeptide amidohydrolase, EC3.5.1.28. This human serum protein (Ladesić et al, 1981; Valinger et al, 1982; Hoijer et al, 1996) has been shown to be produced in the liver. NAMLAA is found in granulocytes (neutrophils, eosinophils), macrophages, and platelets (Hoijer et al, 1997)

The enzyme degrades peptidoglycan, a major component of most bacterial cell walls, by hydrolysis of the lactyl bond that connects N-acetylmuramic acid in the glycan strands with L-alanine of the peptide side chain (Valinger et al, 1982; Vanderwinkel et al, 1995). Because peptidoglycan has inflammatory ... ... ... ...
 
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