MODS |
modular serine protease |
START domain-containing protein 12 |
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[modular serine protease] This Drosophila melanogaster serine protease, encoded by gene CG31217, has been identified by Buchon et al (2009). The protease plays an essential role in the activation of the Toll pathway by Gram-positive bacteria and fungi. ModSP integrates signals originating from the circulating pattern recognition molecules GNBP3 and PGRP-SA and connects them to the Grass / Spätzle processing enzyme / Spätzle extracellular pathway upstream of the Toll receptor. ModSP acts downstream of PGRP-SA, but
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