Met-Val-Arg-Ile-Lys-Pro-Gly-Ser-Ala-Asn-Lys-Pro-Ser-Asp-Asp |
Meucin-13 |
Lesueurin |
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[Metzincin]
This name has been proposed for a superfamily of topologically similar proteolytic enzymes (zinc endopeptidases). Metzincins are mostly multidomain proteins with approximately 130-260-residue globular catalytic domains showing a common core architecture characterized by a long zinc-binding consensus motif, HEXXHXXGXX(H/D), and a methionine-containing Met-turn. These enzymes are, therefore, a subfamily members of a larger group of zinc-dependent enzymes, named zincins, characterised by a shorter consensus sequence, HEXXH, with the two histidines acting as ligands of the catalytic zinc and the glutamate as the general base.
Members of this family include the astacin family, the matrix metalloproteinases (
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