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MMP-28

[matrix metalloproteinase-28] The gene encoding this human metalloproteinase has been identified by Lohi et al (2001), who referred to the encoded protein as Epilysin. MMP-28 has a structure like most other Matrix metalloproteinases. In addition, MMP-28 has a furin activation sequence (RRKKR). The protein does not contain a transmembrane sequence. The exon-intron organization and splicing pattern of epilysin differ from that of other matrix metalloproteinase genes. Lohi et al (2001) have reported that MMP-28 contains a hemopexin domain.

MMP-28 is expressed at high levels in testis and at lower levels in lungs, heart, colon, intestine, and brain and selectively expressed in keratinocytes ... ... ... ... ... Subscribe to continue reading! ... ...

 

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