MIO

[melatonin induced-opioids] Two opioid cytokines acting through kappa-opioid receptors, termed MIO15 (15 kDa) and MIO67 (67 kDa), have been found in the conditioned medium of bone marrow T-helper cells incubated with melatonin (Maestroni et al, 1996, 1998). The two proteins are recognized by antibodies raised against the common opioid sequence (Tyr-Gly-Gly-Phe) and antibodies raised against IL4. Anti-dynorphin B antibodies specifically recognize the 67 kDa protein.

MIO15 seems to mediate the opioid antagonist naltrexone-sensitive effects of melatonin on hematopoiesis (colony stimulating activity and rescue of bone marrow cells from ... ... ... ...
 
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Entry last modified: January 2012