MDAIKKKMQMLK |
MDBK |
B-raf |
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[Musca domestica antimicrobial peptide 2] This peptide (65 amino acids) from the housefly has been identified by Pei et al (2014). MDAP-2 shows in vitro antibacterial activity against all tested Gram-negative bacteria from clinical isolates, including Escherichia coli, one strain of Salmonella pullorum, and one strain of Pasteurella multocida.
Zhang et al (2020) have reported that MDAP-2 is active against Salmonella gallinarum and kills Salmonella gallinarum mainly through direct inhibition of cell membrane biogenesis, interference with energy production / conversion, carbohydrate transport / metabolism, gene expression, as well as the accumulation of reactive oxygen species.
For other proteins/peptides with functions in innate immunity
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