MDA-BF-1 |
MDAIKKKMQMLK |
Evi9 |
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[soluble macrophage-derived anti-HIV factor] This biochemically poorly characterized factor is released from macrophages stimulated with bacterial lipopolysaccharides. It inhibits infection in both CD4(+) T-cells and macrophages by X4 HIV1 strains. MDAF acts primarily at the level of viral entry. MDAF is distinct from several known cytokines that possess anti-HIV1 activity, including IL10, IL12, IL16, IFN-gamma, and alpha-defensins (Mikulak et al, 2009).
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