Mcpt9 |
mCRP |
NALP1 |
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This human mast cell cell line has been generated by lentiviral immortalization of cord blood-derived CD34(+) mast cell progenitor cells. It is used mostly for studies of neoplastic mast cells. MCPV-1 cells express tryptase but lack surface Fc-epsilon-RI. The cells grow independent of SCF and produce a mast cell leukemia-like disease in immunocompromisede mice (Hoermann et al, 2014).
MCPV-1 cells carry an activated ras oncogene, which promotes cell surface expression of CD52. The CD52-targeting antibody alemtuzumab induces
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