MCHWAGGASNTGDARGDVFGKQAG |
MCIF |
Ca2+-binding protein from mouse Ehrlich ascites tumour cells |
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[macrophage chemotaxis inhibitor] This factor is isolated from murine tumor cells. It prevents the migration and accumulation of macrophages in tumor tissues and also inhibits inflammatory reactions (see also: Chemotaxis, inflammation) (Cianciolo et al, 1986). See also: Motogenic cytokines.
This protein is found also in the serum of human cancer patients. The protein is related to a coat protein called p15E found in several retroviruses (MMTV, FLV, MoLV, RLV).
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