MAP3K15 |
MAP97 |
retinitis pigmentosa 10 |
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[Mitogen-activated protein kinase kinase kinase kinase-3] abbr. also MAPKKKK3. Other designations are MEKKK 3 [MEK kinase kinase 3; MAPK/ERK kinase kinase kinase 3]. This kinase has been identified originally as GLK [Germinal center kinase-related protein kinase] (Diener et al, 1997). Diener et al (1997) have shown that this kinase activates c-Jun N-terminal kinase. For an ortholog in Drosophila melanogaster see: happyhour.
Role in cell death by apoptosis
Lam et al (2009) have identified MAP4K3 as a pro-apoptotic kinase in an RNAi
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