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Happyhour

gene symbol: hppy. This Drosophila melanogaster gene is encoded by gene CG7097. Happyhour has been identified in a genetic screen for genes regulating the behavioral effects of ethanol. Mutants show increased resistance to the sedative effects of ethanol. The EGF signaling pathway regulates ethanol sensitivity in Drosophila and happyhour functions as an inhibitor of the pathway. Acute pharmacological inhibition of the EGF receptor (EGFR) in adult animals alters acute ethanol sensitivity in both flies and mice and reduces ethanol consumption in a preclinical rat model of alcoholism.

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