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Limyin

This 6.8 kDa peptide has been isolated from Phaseolus limensis (lima beans) (Wang et al, 2009). Its N-terminal sequence (KTCENLATYYRGPCF) shows high homology to plant defensins. Limyin potently suppresses mycelial growth in Alternaria alternata, Fusarium solani, and Botrytis cinerea. Its antifungal activity is stable up to 80 degrees C. The peptide shows antiproliferative activity towards tumor cells including human liver hepatoma cells Bel-7402 and neuroblastoma cells SHSY5Y. It has no effect on bacteria Staphylococcus aureus and Salmonella.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.

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