Leridistim
This protein is a member of the myelopoietin family of engineered chimeric cytokines that functions as adual receptor agonist. The protein binds IL3 and G-CSF receptors (Monahan et al, 2001). See also: Muteins.
Leridistim is a more potent stimulator of hematopoietic proliferation and differentiation (colony formation by BFU-E, CFU-GEMM and CFU-Mk) than the single receptor agonists (Abegg et al, 2002). Ex vivo culture of peripheral blood or bone marrow CD34(+) cells with leridistim substantially increases total viable cells over cultures stimulated with G-CSF, SC-65303 (an IL3
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