Laminin-beta-1-LN-LE1-4
Laminin-111 is one of the first extracellular matrix proteins expressed during early embryogenesis (see also: Laminins). Laminin-111 is assembled into the basement membrane, providing physical support and modulating extracellular matrix functions (Aumailley, 2013; Hohenester and Yurchenco, 2013).
Horejs et al (2014) have reported that processing of laminin-111 by matrix metalloproteinase MMP-2 yields a biologically active 60 kDa fragment (Laminin-beta-1 60 kDa fragment) of the beta-1 chain that is highly up-regulated during differentiation and functions as soluble signaling molecule. This fragment, termed laminin
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