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(approved gene symbol) [LYR motif containing 1] This gene is expressed highly in omental adipose tissue of obese subjects but expressed also in other tissues. Ectopic LYRM1 expression does not significantly affect adipogenesis. LYRM1 promotes pre-adipocyte proliferation and can inhibit cell death by apoptosis of pre-adipocytes, suggesting that LYRM1 may modulate the size of the pre-adipocyte pool and influence adipose tissue homeostasis. (Qiu et al, 2009).

Free fatty acids and TNF-alpha upregulate LYRM1 expression in 3T3-L1 adipocytes, whereas resistin and rosiglitazone inhibit expression (Zhang et al, 2012).

Cao et al (2010) have reported that overexpression of LYRM1 in ... ... ... ... ... Subscribe to continue reading! ... ...


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