LYRIC |
LYR motif containing 1 |
Tumor cell-targeted cytokine gene transfer |
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(approved gene symbol) [LYR motif containing 1] This gene is expressed highly in omental adipose tissue of obese subjects but expressed also in other tissues. Ectopic LYRM1 expression does not significantly affect adipogenesis. LYRM1 promotes pre-adipocyte proliferation and can inhibit cell death by apoptosis of pre-adipocytes, suggesting that LYRM1 may modulate the size of the pre-adipocyte pool and influence adipose tissue homeostasis. (Qiu et al, 2009).
Free fatty acids and TNF-alpha upregulate LYRM1 expression in 3T3-L1 adipocytes, whereas resistin and rosiglitazone inhibit expression (Zhang et al, 2012).
Cao et al (2010) have reported that overexpression of LYRM1 in
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