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LICE-2

[lymphocytic ICE-2; ICE = IL1-beta converting enzyme] This murine protein (340 amino acids) is a member of the protein family known as caspases. The mRNA is expressed in various tissues except brain. Alternative splicing of this gene yields 3 distinct isoforms (LICE-2-alpha, LICE-2-beta, LICE-2-gamma) (Juan et al, 1997).

The protein has been renamed Caspase-7. The human counterpart is MCH3.

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