LGPF

[leukemia-growth-promoting factor] This biochemically uncharacterized factor of approximately 25 kDa is found in the conditioned medium of the thymic reticuloepithelial-like cell line B6TE. LGPF stimulates the growth of a murine leukemia subline (L17R).

The factor is not identical with IL1, IL2, IL3, and GM-CSF. The growth of L17R leukemia cells is not only stimulated by LGPF, but also by pituitary and brain fibroblast growth factor (see: FGF). It has been suggested that LGPF may be a member of the FGF family of proteins (Miyazawa et al, 1983, 1985). For other leukemia-associated ... ... ... ...
 
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Entry last modified: October 2009